Endocrine Abstracts

Introduction: Malignant pheochromocytoma (MPheo) is diagnosed by the presence of invasion of adjacent structures or distant metastasis. Predictive factors of malignancy for pheochromocytoma (Pheo) are not well known.Material and methods: We retrospectively analyzed clinical, biochemical, radiological characteristics as predictors for malignancy in patients with Pheo in two Spanish tertiary hospitals during the past 35 years. We also evaluated time of rec...

Background: Retrospective, transversal and analytical study was designed to determine the relationship between ApoB/ApoA1 ratio, Non-HDL-Cholesterol/HDL-Cholesterol ratio and Metabolic Syndrome (MetS) in type 2 diabetes mellitus (T2DM) patients attending routine follow-up in outpatient clinic from Madrid.Methods: The study was performed at the University Hospital Infanta Leonor, a public health center, and specialized secondary referal, which provides se...

Aim: To assess a perioperative glucocorticoid protocol in transsphenoidal surgery (TSS)and the performance of early post-TSS 08:00 cortisol measurement to detect/exclude secondary adrenal insufficiency.Methods: We selected patients undergoing TSS.In patients with no cushing disease, we checked cortisol/Synachten presurgery, measured 3° postoperative 0800 a.m. cortisol(after 24 h without corticoids) and cortisol/Synachten 3-6 months post-surgery. We ...

Cardiovascular disease (CVD) is more prevalent in patients with chronic kidney disease (CKD) and Diabetes mellitus (DM) than in the general population. Microparticles (MPs) released during cell activation and/or apoptosis could be biomarkers of CVD. These MPs, which show vascular damage, are named according to the injured cell, as endothelial (EMPs) or platelet (PMPs).AimAssess the MPs plasma concentration in diabetic pati...

ObjectiveThe aim of the study was to evaluate the overall malignancy rate on final histopathology in nodules with Bethesda III or IV surgically excised and review the ultrasound and cytological features givenMaterial and methodsIs a retrospective analysis of patients referred to our outpatient clinical of endocrinology after thyroid surgery with a previous thyroid nodule FNA cytology in Bethesda III or IV cat...

Background: Silver-Russell syndrome (SRS) is a unique disorder characterised by characteristic features and growth restriction due to 11p15 LOM or upd(7)Mat in ~60% cases. Monogenic defects are a rare cause of SRS and HMGA2 mutations have been identified in 4 cases to date. The function of HMGA2 is poorly understood.Objectives: Assess the clinical phenotypes of 6 new patients with novel heterozygous HMGA2 defects and evaluate t...

Objectives: The transition from the paediatric age to the adult is a particularly vulnerable period in patients with metabolic congenital diseases (mcd). In andalusia two adults’ units exist (seville and malaga) for the follow-up of these patients. Our aim in this study was to evaluate the current series of attended patients.Material and methods: We evaluated all patients transferred to the adult units since 2008. The clinical records were analyzed ...

Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors leading to transcriptional repression. Genomic studies have shown the presence of inactivating mutations of the NCoR gene in human tumours and we have found that NCoR depletion with siRNA in hepatocarcinoma SK-hep1 cells enhances invasion, tumour growth and metastasis in nude mice, while expression of the thyroid hormone receptor β (TRβ) increases NCoR levels, repr...

Introduction: The incidence of thyroid cancer (TC) is low, but rising over time. Some studies point to a possible increase in mortality rate (MR) from this cancer in certain areas of Spain and Andalusia. Our purpose was to analyse the TC mortality in Andalusia and study how it has changed in the last years. We also analysed differences by age, sex, and geographic area.Methods: All deaths from TC were collected between January 1, 1975 and December 1, 2011...

Introduction: Primary tumours in some patients with metastatic neuroendocrine tumors (NET) cannot be found by conventional imaging as CT, MRI and scintigraphy. 68Ga-DOTATOC PET/CT (68Ga-PET) appears to have superior sensitivity, specifity, and better resolution than 99mTC-octreotide SPECT/TC (SSTR scintigraphy) and can improve decision-making process, however its cost is higher, and its availability is limited.Aims: Evalu...